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rpmE [2017-8-11 16:0:3]
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rpmE [2017-8-11 16:0:3]

ribosomal protein
locus
BSU37070
pI
9.16
mw
7.31 kDa
protein length
66 aa Sequence Blast
gene length
198 bp Sequence Blast
function
translation
product
ribosomal protein L31
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.4|Ribosomal proteins]

    • Gene

    Coordinates
    3,803,081 → 3,803,281

    Phenotypes of a mutant

  • delayed spore [SW|germination] [Pubmed|25661487]

    • The protein

    Protein family

  • Type A subfamily (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|DAE7AB27A4C42BF50556BB76F33BEFA8DF35EA3A|RpmEB]

    • [SW|Cofactors]

  • requires zinc for activity [Pubmed|19648245,15049826]

    • Structure

  • [PDB|3J9W] (the [SW|ribosome]) [Pubmed|25903689]

    • Additional information

  • Under conditions of zinc starvation, RpmE is replaced by its paralog [protein|DAE7AB27A4C42BF50556BB76F33BEFA8DF35EA3A|RpmEB], that does not require zinc [Pubmed|15049826]

    • Expression and Regulation

    Operons

    genes
    [gene|035154A4160F084BA1CC124D0951937B203E167D|rpmE]
    description
    [Pubmed|9353933]

    regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, in [regulon|stringent response|stringent response]
  • [protein|035154A4160F084BA1CC124D0951937B203E167D|RpmE]: autorepression, [pubmed|32448158], in [regulon|035154A4160F084BA1CC124D0951937B203E167D|RpmE regulon]

    • regulation

  • autorepression of [gene|035154A4160F084BA1CC124D0951937B203E167D|rpmE] expression upon binding of excess [protein|035154A4160F084BA1CC124D0951937B203E167D|L31] to a [SW|RNA switch] in the untranslated region of the [gene|035154A4160F084BA1CC124D0951937B203E167D|rpmE] mRNA [Pubmed|32448158]
  • [protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
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    genes
    [gene|7CD46C64BE69EDADF58B634DC50C3F61BFFEC5B5|rho]-[gene|035154A4160F084BA1CC124D0951937B203E167D|rpmE]
    description
    [pubmed|22383849]
    view in new tab

    References

  • 17163968,15049826,19648245,19653700,20208344,23002217,25661487,25903689